The fate of Group D in the current season of the UEFA Champions League looks more or less sealed. The European football giants Juventus and Atletico Madrid are at the top of the league table after seven games each of three games, with the latter only slightly dependent on the goal difference and are most likely to move into the next round.
Bayer Leverkusen's hopes of surviving the match failed in the final match of the Champions League with a 1-0 loss to Atletico Madrid.
From now on, Lokomotiv Russia will have to win every game to stay alive on the hunt for further progress. The road, however, looks extremely difficult.
-Juventus travels to Moscow without injured de Ligt
Juventus will play against Lokomotiv Moscow in Russia without the involvement of its main defender Matthijs de Ligt, who will fail due to an ankle injury.
After defeat in the derby against Turin in Serie A on Saturday, center-back De Ligt was diagnosed with "a slightly sprained left ankle".
The 20-year-old was consequently expelled from a Juve team that will qualify from Group D with a win over Lokomotiv in Moscow.
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Although one of his main defenders will be out of action, Sarri will not be too worried when his side go into the away game following a 1-0 victory over Turin in the Turin derby. Juve has won nine of his last 10 games and, interestingly, six of them have won 2-1.
At the last meeting of these two teams, the defending champions of Serie A won 2-1.
Lokomotiv Russia, currently third in the Russian Premier League, receives Juve in a du-or-die match. For coach Yuri Semin it got worse as Jefferson Farfan, Luka Djordjevic, Anton Miranchuk, Fedor Smolov and Boris Rotenberg were injured.
-Bayer boss Peter Bosz hopes for a miracle against the solid Atletico Madrid
Despite three defeats in their first matches, Bayer Leverkusen boss Peter Bosz is confident he can win against Atletico Madrid on Wednesday to fulfill his hopes of a tight knockout phase and a miracle of the Champions League.
Defeats against Lokomotiv Moscow, Juventus and Atletico leave Leverkusen without a point at the end of Group D with only three games remaining.
It's been more than 15 years since a team made progress in the Champions League despite being defeated in their first three games when Newcastle United took second place in the 2002-03 group stage and won all three games.
Nevertheless, Bosz wants to beat Atletico, who beat his team 1-0 in Madrid two weeks ago, and scored seven points with Juventus at the head of the group to postpone his European campaign.
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"The chance is low, but still there," said Bosz defiantly on Tuesday.
"There are still nine points left in the group. I'm a fighter and I'll just say it's over, if it really is.
"We want to stay in the European competition after the winter break, so we need points."
Leverkusen defender Sven Bender, who has lost just against Alvaro Morata in their last game in Madrid, is hoping for a chance against Atletico.
"We've stayed in Madrid, we have what it takes to beat Atletico and we want to do everything we can to win on Wednesday," said the former German defender.