The Labor MP Keith Vaz, who has said he has not been in a position to remonstrate for six months.
Vaz, 62, was announced in a statement on Sunday evening.
He said, "I've decided to retire after completing 32 years as a member of Leicester East. In that time I have won eight general elections. It has been an honor and a privilege to serve my constituency since I came to the city in 1985.
"I want to thank the people of Leicester East for their absolute loyalty and support. Leicester and especially the people of Leicester East always wants to be in my heart. "
The Labor leader, Jeremy Corbyn, said, "Keith Vaz was among the pioneering group of black and Asian Labor MPs in 1987. I was proud to support his selection and incredibly proud when he won, taking the seat from the Tories.
"Keith has made a substantial and significant contribution to public life, both as a constituency MP for the people of Leicester and for the Asian community across the country. BAME people become involved in politics.
The first Asian origin minister, chair of the home affairs select committee, a campaigner on diabetes issues and most recently trying to help the peace process in Yemen. Our work to combat racism and bring our diverse communities together is far from over. "
The Leicester East MP's resignation comes after the standards committee found that he was "facing significant damage to the reputation and integrity of the House of Commons."
Vaz faced an inquiry into claims published in the Sunday Mirror in 2016 that he had offered to buy drugs for male escorts while pretending to be an industrial washing machine salesman. Following the newspaper sting, Vaz denied he was asked to pay for sex, claiming the purpose of the meeting.
The inquiry found the MP's explanation, which included that he had amnesia and could not remember key events, to be "not believable and, indeed, ludicrous". Vaz what banned from parliament for six months.
There were calls for Vaz's resignation within Labor's national executive committee, with the shadow home secretary, Diane Abbott, saying, "I think he should consider his position. I think he himself should not be a candidate. "
The Labor MP has been in harsh breach of the MPs' Code of Conduct and is in the process of reviewing the matter for a month in 2002 for "perverting the course of justice".