Liverpool duo James Milner and Joe Gomez are both pushing for recalls, but keeper Alisson and Nathaniel Clyne are still missing.
Midfielder Naby Keita is expected to return to training in the coming days following a calf injury in the preseason.
Sean Longstaff has to go to Newcastle after twisting his ankle in training.
Matt Ritchie, Allan Saint-Maximin, Andy Carroll, Dwight Gayle, DeAndre Yedlin and Florian Lejeune are also unavailable to Steve Bruce.
MOTD COMMENTATOR'S NOTES
@ Guymowbray: It's unlikely that a game that spawned two of the Premier League's most memorable games in the 1990s will now give us the same thrill.
Like then, Liverpool should win, but if it takes a late goal a la Collymore or Fowler, something went wrong – and Newcastle will have done (almost) everything right.
They won in their last away game in Spurs thanks to a disciplined defensive performance. A similar but even better performance is needed in a stadium where Newcastle has only won twice in the league in 46 visits since 1950.
Maybe a Brazilian striker is the key? Mirandinha 1988. Joelinton 2019?
LOOK FROM THE LOWER
Liverpool coach Jürgen Klopp: "Steve Bruce certainly has a difficult job, but he has done a fantastic job so far, keeping the style of last season, selling Rondon, getting Joelinton and he's similar, they have speed for counters."
"It's not going to be easy, people probably expect it, but I'm really impressed with the solutions they've found so far."
Steve Bruce, head coach of Newcastle United: "We go to the European champions and they are better than ever before, so we have to defend well."
"It has always been a big challenge, and you want to go there and take it over, that's what we're here for, the core of the team has been around for a few years, and they're a truly honest and genuine group.
"If you have that, you're capable of anything, you went to Spurs and won and last year defeated Man City, so they're in it."
I'm sure Magpies boss Steve Bruce will be setting up his squad just as he did in Tottenham. He has camped in his own half to stifle Liverpool, but I see that it does not work this time.
Lawros full forecasts against MOTDx stars Chelcee Grimes, Craig Mitch and Reece Parkinson
head to head
- Newcastle has lost 75 top games against Liverpool, more than any other team.
- Liverpool have been unbeaten in the last 23 home matches against the Magpies (W19, D4) and have scored in each of these games.
- Newcastle last won 2-0 in Anfield in April 1994.
- Liverpool have scored 98 Premier League goals in this game.
- They are vying to become only the fourth English team to win 14 top matches in a row and the first to score more than once in each game.
- The team of Jürgen Klopp is unbeaten in 42 league games in Anfield since April 2017 (W32, D10).
- The Reds achieved their Premier League record of 10 home wins in a row.
- Liverpool have scored 17 goals in 17 home games since last October's goalless draw with Manchester City.
- Eight of Liverpool's 12 goals this season were scored in the first half.
- Mohamad Salah has scored in each of his last three Premier League games against Newcastle.
- Newcastle have won three of their last five away games, more than in the last 24 attempts.
- The Magpies have met in six of their seven away games away.
- Since defeating Derby in 1972 (D5, L22) they have been without victory in 27 away games.
- Miguel Almiron has been caught offside seven times in the league, four times more than the entire Liverpool team combined.
- Steve Bruce has won just one of his 12 league games as manager at Anfield (D7, L4).