Women who have suffered recurrent miscarriages will participate in an innovative trial to determine if antibiotics could reduce inflammation of the uterus and increase the rate of live births.
Recurrent miscarriages, the loss of three or more consecutive pregnancies, affect thousands of couples each year across the UK, and a quarter of pregnancies end in miscarriage.
As part of her research on repeated miscarriages, Professor Siobhan Quenby and her team at the University of Warwick are studying chronic endometritis, an inflammatory condition of the lining of the uterus.
The National Institute for Health Research received £ 1.9 million for the first-ever controlled trial of antibiotics in hopes of reducing endometrial inflammation.
Previous research has shown that women with higher levels of inflammation of the uterus had a 60% chance of having a baby, compared to 80% for those with lower levels.
The women recruited for the trial, who will accept applications via a website launched in October, will be divided into two groups: those with mild inflammation and those with a higher level of inflammation.
Half of each group will receive the antibiotic doxycycline and the others will receive a placebo.
Women will be monitored throughout the study to determine if antibiotics reduce inflammation and increase the birth rate, with regular monitoring and testing to ensure that patients are not adversely affected.
Professor Quenby told Sky News: "This four-year trial will answer many questions.
"We will recruit for two years, then we will allow time for pregnancies and births.Parents and families are embarrassed by miscarriage, people have lost all hope in their baby and need to talk to others about their loss."
Endometritis may cause bleeding and pain in some women, while others may show no obvious indication.
There is no standard screening test for endometritis, so researchers will also try to develop tests to identify women with this condition in the future.
The study aims to reduce the rates of miscarriage by 50%.
Professor Quenby added, "Our goal is to try to improve the uterus before getting pregnant.Most miscarriages occur in the first 12 weeks of pregnancy and our goal is to see a reduction of these early miscarriages. "