Scientists at the Healthcare Technologies Institute, University of Birmingham (UK), have developed a nasal spray that could provide effective protection against the new coronavirus.
The research with which the idea of the spray was born, and which has not yet been peer reviewed, concluded that This inhibits infection for up to 48 hours after being applied, prevents infection through the nasal passage and reduces the transmission of the virus from person to person.
(Also read: Learn about the three most advanced vaccines against covid-19).
According to him report Published by the University of Birmingham, the spray works in two ways. First, it traps the virus inside the nose and coats it. From there it can be eliminated by the usual routes: blowing the nose or swallowing.
Secondly, prevents the body from absorbing the virus because it is wrapped within the viscous layer of the spray. This means that the viral load in the body will be reduced.
In the same way, the research showed, if the virus particles are transmitted to another person, through a sneeze or cough, whoever applied the spray is less likely to become infected.
The invention consists of an antiviral agent called carrageenan, which is commonly used in foods as a thickening agent, and a solution called gellan, which attaches to cells inside the nose. The latter has the ability to stay inside the nasal cavity instead of sliding down and out of the nose.
(You may be interested: Coronavirus genetic mutation could make it more contagious).
If the virus particles are transmitted to another person, through a sneeze or cough, the person who applied the spray is less likely to become infected.
“Although our noses filter thousands of liters of air each day, there is not much protection against infection and most airborne viruses are transmitted through the nasal passage. The spray that we have formulated provides that protection, but it can also prevent the virus from being transmitted from person to person, “said Professor Liam Grover, a co-author of the research.
The team believes that The spray could be particularly useful in enclosed areas such as airplanes or classrooms and that sconstant application could significantly reduce disease transmission.
“Products like these do not replace existing measures, such as the use of masks and hand washing, which will continue to be vital to preventing the spread of the virus, “added Dr. Richard Moakes, lead author of the report. “
“However, what this spray would do is add a second layer of protection to prevent and slow down the transmission of the virus,” he adds.
(Also read: Wastewater analysis helps predict spread of covid).
The materials that make up the spray are licensed by regulatory bodies in Europe and the United States, and are widely used in medical devices, drugs, and even food products.
With this in mind, the complex procedures required to bring a new product to market would be simplified and, for this reason, the spray could be available for commercialization very soon, although it needs peer review and more testing first.
“This spray is made from readily available products that are already being used in food and medicine products, and we deliberately incorporated these conditions into our design process. It means that, with the right partners, we could start mass production in a few weeks, “said Dr. Moakes.
(You may be interested: G20 commits to financing covid vaccines for poor countries).
Mining engineers, geologists and mining companies They have prepared an analysis document of the Climate Change bill that loads frontally and harshly against the amendment agreed by the PSOE and United We Can to prohibit the investigation and exploitation in Spain of radioactive mineral deposits. The report, sent to the congressional parliamentary groups, maintains that the initiative approved by the partners of the Government coalition “violates legal security, does not have a legal basis, its technical justification is erroneous and does not carry out an adequate analysis of its consequences. environmental or economic “. The document asks for a negative vote on the amendment.
The report is signed by the dean-presidents of the Higher Council of Colleges of Mining Engineers -Ángel Cámara- and of the General Council of Official Associations of Technical Engineers and Degrees of Mines and Energy, José Luis Leandro Rodríguez. The president of the Official College of Geologists, Manuel María Regueiro and the president of the Spanish Confederation of Mineral Raw Materials Industries (Primigea), Javier Nameplate.
The signatories share the idea that if the bill maintains the ban on the exploitation of radioactive minerals, it will be raising “serious doubts of unconstitutionality and against the doctrine of the Strasbourg Human Rights Court.” The document explains in this sense that the amendment agreed by the PSOE and UP violates, among others, articles 31.3 and 128.2 of the Constitution that recognize the right to private property and expropriation with compensation and article 132.2 that recognizes mining resources as public domain. Furthermore, the document assures, (the amendment) “is contrary to the constitutional doctrine that establishes the extraction of mineral rights as a priority for national wealth.”
The Berkeley Plan
The report does not mention at any time the Australian mining group Berkeley, directly affected by the prohibition contained in the bill. Berkeley has been promoting a controversial plan to extract uranium in Retortillo (Salamanca) for a decade, which is pending procedures in the Nuclear Safety Council (CSN). Although the document does not mention the Australian mining company, it does indicate that the plan to prohibit the extraction of uranium supposes in practice “a single case law, since it actually refers materially to a very limited number of cases · and therefore “is radically contrary to the doctrine of the Strasbourg Human Rights Court, which demands in these cases, the right balance, with inescapable compensation”.
The mention of the Strasbourg Court and the Community regulation through EURATOM of the uranium trade, serves as a clue as to where Berkeley’s legal claims may go if the law is passed. The mining group’s line of defense has two key points: a report in favor of the Euratom mining project, the European public body in charge of coordinating nuclear energy research programs, and a list of the 120 permits granted since 2010 in Spain by the central, regional and local administrations. The multinational, which has entrusted the legal battle to the Herbert Smith Freehills law firm, has so far won the appeals raised against it by environmental organizations.
The report of engineers and geologists specifies the scope of the debate. It details that, as of October 2020, there are 29 uranium mining rights in force in Spain, of which 18 are granted and 11 are in the process of being granted. Of all of them, nine refer to exploitation concessionsTherefore, they would be “pre-existing consolidated rights that must be compensated by the State for amounts, without any doubt, considerably higher than the perfectly evaluable economic costs that are intended to be avoided.”
In the document, the pandemic, “which has revealed the weakness of the foreign supply chain” also becomes an argument in favor of exploiting own mineral resources so as not to compromise “the security of supply of Spain and the European Union for a critical and essential mineral raw material (uranium) “. In this sense recall that the EU is committed to European electricity interconnection “being France the largest producer of nuclear energy“If Spain bans uranium, they argue, it would be denying France” the possible supply of raw materials from European sources. “
If the amendment in the bill succeeds, the legal battle can be long. Berkeley has shown in the past that it does at least as well in court as it does on the stock market. In 2012, the Australian group led the National Uranium Company (ENUSA) before the International Court of Arbitration for having backed down in the project for the joint exploitation of uranium in Salamanca. So claimed $ 200 million (150 million euros). The case was closed with an agreement on exploitation rights in the area, but it showed that Berkeley defends the conquered ground to the end.
“Imposing sanctions on some economic sectors is possible,” Boone said, adding that “all options are on the table,” including individual sanctions.
During an interview with the radio program “Europe 1” and the newspaper “Les Echos”, the French minister pointed out the sanctions that had been taken against some Turkish officials for gas exploration in the Mediterranean.
“We had an opportunity at the recent European summit for Turkey, which sent small hints of calm and has now chosen once again the path of provocation and systematic aggression,” Bonn said, adding: “We will definitely go further.”
Bonn stated that “over a period of 10 or 15 years, we believed that Turkey was a peaceful democracy-Christianity in the eastern form accompanied by a gradual contemporary”, adding: “This was not the case, it adopts an Islamic culture and geopolitical approach hostile in all fields. Again in Nagorno Karabakh recently, so we must not be naive. “
Bonn emphasized that “France is not the only one facing Turkey today, and there are no illusions in any European country about what Erdogan and his regime are.”
Notably, differences have intensified between Turkey and the European Union since last August, in the context of the first gas exploration in the eastern Mediterranean.
After having celebrated the victory of Democrat Joe Biden in the US presidential elections, the excitement toured the world stock markets with the announcement of an effective vaccine against covid-19.
With the announcement at noon in Europe by the Pfizer and Biontech laboratories that their vaccine would be “90% effective” against covid-19, markets exploded.
At around 11:20 GMT, Paris registered an increase of more than 7%, Frankfurt of more than 6%, London and Milan were more than 5%. Altogether, the European markets registered their best results in a session of the last six months.
In the United States, futures contracts, which allow the trend to be known before transactions begin, followed the same direction, with the Dow Jones increasing by 5.30%.
On the other hand, the Nasdaq, whose stocks were the great beneficiaries of the effects of the pandemic, presented a moderate rise of 0.77%. Oil prices were also accelerating: around 12:10 GMT, a barrel of Brent from the North Sea for January delivery was up 7.58% compared to Friday’s close, to $ 42.44.
In New York, a barrel of WTI with delivery in December grew by 8.78%, to $ 40.40. “This news is huge, we have been waiting for it for a long time,” said Daniel Larrouturou, who manages shares at Dôm Finance, asked by AFP in Paris just after the announcement.
“This is the news of the year, maybe even the decade. The coronavirus vaccine has been found,” Jochen Stanzl, analyst at CMC Markets, said in Frankfurt. “Almost nothing could be more beautiful than this information after four years of transatlantic divisions under the Trump administration,” he added.
Before the announcement that spread enthusiasm in Europe, the Asian and European markets savored the victory of Democrat Joe Biden in the US presidential elections.
In Asia, the Nikkei star index of the Tokyo stock market, which has already risen close to 6% in all of last week, closed with a rise of 2.12%. In the debt market, the appetite for risk was crushing the sovereign indices of the countries considered to be riskier, such as Greece and Italy, whose 10-year indices reached new historical lows, respectively at 0.728% and 0.617%.
JOY OF SOME …
The announcement benefited all the sectors most affected by the activity restriction measures, such as travel, aeronautics or banks. The news from the labs triggered supersonic increases at Airbus (+ 20%), IAG (+ 30%), Lufthansa (+ 30%), Rolls Royce (+ 29%) and Easyjet (+ 25%).
On the contrary, the companies that benefited from the lockdown measures registered steep falls: in Frankfurt, Delivery Hero (food delivery to home) was the only value in the red (-4.45%), in the MDax (index of German average values) Hello Fresh (delivery of food basket to cook at home) lost 18.2%.
In London, Ocado fell 8.26% and Just Eat Takeaway, 7.14% This announcement comes at a time when the United States, like Europe, face records of new infections in recent days and that the accumulation new restrictions to stop the second wave could seriously damage the economic recovery.
Thus, the prospect of a health improvement gained ground with the victory of Joe Biden, from whom “the stock markets expect greater predictability and less volatility,” Stanzl points out. Investors have no doubt that Joe Biden will become US president in January, even if Donald Trump still doesn’t want to admit defeat.
“Investors believe that his legal recourse only represents an attempt to save the image” of the outgoing president, analyzes Joshua Mahony, an analyst at IG. At first, investors feared a Democratic victory, synonymous with increases in corporate taxes and taxes on capital income, but now they are betting on moderate policy measures.
Well, “it seems likely that the Republicans will retain control of the Senate, and if they did, it would be more difficult for the Biden administration to introduce stronger regulation for the tech and pharmaceutical sectors, as well as raise taxes,” observes David Madden, analyst for CMC Markets. .
In currencies, the dollar fell 0.07% against the euro, to 1.1882 dollars for one euro, and the yen fell 1.00% against the dollar (104.41 yen) and 1.10% against to the euro (124.08 yen).
The covid-19 epidemic has hit hard and by surprise. The scientific world has been working from the beginning to find solutions that allow to contain and prevent the disease effectively. It is hard work as it requires time, effort, and investment. And the hopes are above all on the possible vaccine that allows to face the disease by coronavirus with greater peace of mind, both individually and collectively.
“Some anti-aging strategies, due to their action at the cellular level, can improve the defenses of our elders”
Between the risk factor’s associated with a greater morbidity and mortality due to covid-19, have been found, among others, the obesityand associated metabolic disorders such as diabetes o la hypertension arterial, in addition to cardiovascular disease previous or the respiratory insufficiency. And, no doubt, contracting the disease at a advanced age it has been one of the worst predictors. We have all lived with despair the news that pointed out how the virus was preying on our elders.
Why is this high mortality at advanced ages? Undoubtedly, all the alterations that we have indicated and that predispose to a worse prognosis are more frequent among the elderly. Just look at the arterial hypertension, whose prevalence soars after 65 years, affecting 70% of the population. But another reason is undoubtedly the aging of our defenses, in what is called immunosenescence.
Our defense system against infections It is made up of a multitude of components, which among others can be classified as humoral immunity (the famous immunoglobulins that are measured in the IgA and IgM antibody tests) or cellular (the lymphocytes T or B). Aging can negatively affect both the number of cells (leukocytes) and their level of activity.
For example, older adults generally have fewer naïve T cells that respond to attack by a new invader, or B cells that produce antibodies. In addition, in older people there is an imbalance in the production of inflammatory substances, necessary to combat any infectious process. It is what is called in English ‘inflammageing‘, joining the terms’ inflammation’ and ‘aging’ (inflammation and aging). This state, of low intensity chronic inflammation, makes our immune system less ‘sensitive’ to external stimuli, such as an infection or a vaccine.
All of this can explain the greater susceptibility of the elderly against covid-19. But it is also a cause for concern, because the effectiveness of some of the more than 50 vaccines in development it could be greatly reduced in the elderly. Experience with vaccines such as influenza indicates that it may be necessary to enhance them to improve their effectiveness in the elderly, either with a higher dose viral antigen, either by using adjuvants. But that strategy can be difficult to apply in a race against time such as that of the coronavirus vaccine, since specific clinical trials would have to be developed.
Speaking of ongoing trials, some of them, such as phase 1 developed by Moderna in the US, indicate that the response in people over 56 years of age is similar to that found in young people. Another trial, Sinovac’s in China, has also found good results in older adults around the age of 89, compared to adults in their 60s. However, the Pfizer study with BioNTech in Germany shows an effectiveness in older people that is halved than in young adults. And we do not know if those levels will confer virus protection. In addition, a analysis recent 18 clinical trials of vaccines against covid-19 found that many of them could be excluding for different reasons to elderly subjects, which would mean that the results may not accurately reflect the impact of these vaccines in the elderly.
At this point, what alternatives are there? One of them could be enhance the action of the immune system. And for this, the anti-aging strategies could be the answer. One of the strategies that we already mentioned in this space, diet that mimics fasting de Valter Longo, found that the immune system was somehow ‘reset’ due to caloric restriction. One of the mechanisms by which hypocaloric diets or fasting seem improve longevity in animal models it is the inhibition of a metabolic pathway related to cell replication, which is called mTOR. Could this help improve immune function?
That is what was proven in a study using an mTOR inhibitor, to see if the risk of infection. This substance was administered for six weeks and it was observed that the subjects in the intervention had a lower risk of infection in the following year and a better response to flu vaccine. With these precedents, other mTOR inhibitors are currently being tested, similar to the rapamycin, to verify if they can reduce the risk and severity of covid-19 infection, given the history of a positive effect with other coronaviruses.
Another possible candidate to improve the response of the immune system would be the metformin, of which we already spoke in this space recently. It has been possible check that diabetic patients treated with this drug have a lower risk of dying or being hospitalized for the disease. Apparently, obesity and diabetes can induce an immune deficit similar to that of advanced age, which is why a clinical trial with metformin will be launched to assess whether it can prevent or reduce the effects of COVID-19 in the elderly; and another trial that will check whether this drug improves the effectiveness of the flu vaccine in this group. These two jobs could open the door to its use to improve the response to the vaccine against the virus in the elderly.
When cells shorten their telomeres, reaches a limit in which they can no longer be replicated and go to what is called state of aging. These ‘zombie’ cells that do not initiate the process of apoptosis or programmed cell death have detrimental effects on other cells since they secrete a whole series of substances that negatively affect the function of those that are still active. Senolytics are substances that favor the elimination of this type of cells, such as quercetin, found in foods such as Apple, the onion or capers, and which also, by the way, has antiviral activity. Wave physics, found in the strawberries and that the Mayo Clinic in the US is testing in a trial with 70 over 60s to assess whether it reduces the impact of the new virus. This could be a third line of action, along with mTOR inhibitors or metformin.
These strategies, used before administering the vaccine against covid-19, could improve its effectiveness and also do so without the need to develop formulations with a specific dosage or preparation for this group of older people. An aging immune system is a weaker and poorly regulated immune system. Some anti-aging strategies, due to their action at the cellular level, can improve the defenses of our elders. Something very necessary in these times.
Betis could not obtain revenue in his visit to Barcelona and ended up thrashed in a game in which his lack of forcefulness in containment weighed on him, with the double pivot and the defense completely surpassed. In the first part he kept the type thanks to the little Barça success already the offensive projections of a very active Álex Moreno in attack but unassisted in defensive tasks.
The side was the most incisive next to the two forwards, which practically marked those that had, both Sanabria leaving start as Loren, from the bench. On the left wing, he lacked the accompaniment of the right hand, much missing at the Camp Nou.
The Peque, located in ninth place in the world ranking, had been eliminated earlier this Friday in Paris after losing in the quarterfinals against Russian Daniil Medvedev (5) by 6-3 and 6-1.
However, Nadal (world number 2) beat Carreño Busta (15) by 4-6, 7-5 and 6-1 and left him with no chance to snatch the place from the Argentine in London 2020, for which he needed not only beat Nadal but also come out champion.
“London, here we go,” tweeted Schwartzman, who is coached by Juan Ignacio Chela.
Diego will be the eighth Argentine to participate in the prestigious singles competition. The previous seven were Guillermo Vilas, José Luis Clerc, David Nalbandian, Guillermo Coria, Gastón Gaudio, Mariano Puerta and Juan Martín del Potro.
For the ATP Finals in London Novak Djokovic, Rafael Nadal, Dominic Thiem, Daniil Medvedev, Stefanos Tsitsipas, Alexander Zverev and Andrey Rublev were already qualified.
Schwartzman stars in an unforgettable year with his access to the finals in Córdoba, the Masters 1000 in Rome and the German ATP in Cologne, and in his best tournament to the semifinals at Roland Garros, where he lost to Rafa Nadal, then champion for the 13th time.
The just reward for his great season, in which he entered the “top ten” for the first time and placed eighth after his performance in Bois de Boulogne, is this qualification for the London Masters, something that an Argentine has not achieved for seven years, when Del Potro from Tandil participated in the 2013 edition.
The ATP Finals in London already had the presence of an Argentine assured, but in the doubles draw: Horacio Zeballos will compete alongside the Spanish Marcel Granollers, with whom he was crowned champion this year in Buenos Aires, Rio de Janeiro and the Masters 1000 in Rome .
Schwartzman, 28 years old and in the best of his career, fell this Friday in just one hour and four minutes of play against the Russian Medvedev, fifth in the ranking, but the great goal of Peque was fulfilled this afternoon, with the qualification to London .
The RUTI vaccine against Covid-19, developed by a researcher at the Germans Trias i Pujol Hospital, in Catalonia (Spain), and manufactured by the Archivel Farma pharmaceutical company, it is the first Spanish to receive authorization to carry out an international clinical trial, which will be carried out in Argentina.
(The coronavirus vaccine that generates immunity in older adults).
As reported by the company, the vaccine, Initially designed against tuberculosis, it is also expected to be effective against other viral infections such as coronavirus, which is why it has received approval from the National Administration of Medicines, Food and Medical Technology (ANMAT) of Argentina to carry out a clinical trial.
This is a double-blind, placebo-controlled study, lasting nine months, to evaluate the efficacy of the RUTI vaccine in preventing infection and reducing mortality from SARS-CoV-2 in healthcare personnel.
(The vitamin that coronavirus patients lack.)
The vaccine has been developed by Dr. Pere-Joan Cardona, from the Can Ruti Microbiology Service, and It is based on the so-called “trained innate immunity”, that is, on stimulating the body’s immunity through the vaccine and “equipping it with memory” to generate a better and faster response to virus exposure.
To be effective, RUTI could become the basis for broad spectrum antiviral vaccines thanks to its alternative mechanism to the generation of antibodies produced by classical vaccination.
(Immunity against coronavirus decreases very rapidly).
In fact, this new therapeutic option could also be used as a first resort in case of epidemics caused by new viruses or in pandemic virus mutations that make existing vaccines lose their initial efficacy.
It could also be applied as a booster in populations that do not respond effectively to specific vaccines or as a complement to vaccines that generate antibodies, for example those developed specifically for Covid-19.
“The concept of trained immunity appears as an interesting and innovative alternative to explore as a prevention strategy, initially on health personnel”, explained the doctor leading the study in Argentina, Waldo Belloso, who has admitted that “obtaining of specific vaccines of sufficient efficacy and available for widespread use will take time. ”
After receiving the endorsement of the Argentine authorities, The RUTI Immune company, created by Archivel Farma to produce the vaccine, has already started the logistical procedures so that the doses reach the South American country and can begin to be administered in 369 employees of various health centers.
In Spain, according to the company, the vaccine could also soon be tested in a very similar clinical trial by the Institut Germans Trias i Pujol (IGTP).
With an unusual display, ‘The New York Times’, one of the most influential newspapers in the United States, published yesterday in its printed version a harsh attack on US President Donald Trump, a few weeks before the date of the elections in which he seeks his re-election.
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The special, which had already been advanced on Friday on the web, and which did not require subscription, drew attention for a devastating opinion article entitled ‘End our national crisis’ in which it is assured that “Trump’s re-election campaign represents the greatest threat to American democracy since World War II ”.
The text, signed by the Editorial Board, a group of journalists defined as separate from the Editorial Board, continue with phrases like:
“Trump’s ruinous term has already severely damaged America at home and around the world. He has abused the power of his office and denied the legitimacy of his political opponents, breaking the norms that have united the nation for generations. Has subordinated the public interest to the profitability of its commercial and political interests. He has shown impressive disregard for the lives and liberties of Americans. He is a man unworthy of the position he occupies (…)”.
Trump’s reelection campaign represents the greatest threat to American democracy since World War II.
The pronouncement was accompanied by several essays that touch on controversial issues of his mandate, such as corruption, demagoguery, populism, environment, the rights of women, immigration and racial discrimination, among others, signed by prestigious pens and that headed several pages of the form.
(Of interest to you: Colombia is in the middle of the US presidential campaign.)
The text concludes with a phrase that shows what is at stake: “November 3 could be a turning point. This is a choice about the future of the country and which path its citizens want to choose ”.
– Why did Twitter suspend Trump’s campaign account for several hours?
– Analysis: What can you expect from the elections in the US?
– Trump and Biden’s Key Points at Their Separate Gatherings
The New York Times newspaper published a harsh editorial on Friday against the president of the United States, Donald Trump, in which it says that the president’s re-election campaign means “The greatest threat to American democracy since World War II.”
(Also read: The key points of Trump and Biden in their separate gatherings)
“Trump’s ruinous term has seriously damaged America at home and around the world. He has abused the power of his office and has denied the legitimacy of his political opponents, breaking the rules that have united the nation for generations, ”the text says.
(It may interest you: The key points of Trump and Biden in their separate gatherings)
Donald Trump will contest the White House with Democrat Joe Biden.
The opinion piece states that the president has shown disregard for the lives and liberties of americans and points out that he is “a man unworthy of the position he occupies.”
In addition, the newspaper recalls that it has condemned the “divisive rhetoric of the president and his attacks on other” Americans. The Times also says that November 3, the day of the presidential elections, may be a “turning point.” “This is a choice about the future of the country and which path its citizens want to choose.”
(Also read: How likely is Donald Trump to be re-elected in the US?)
On the other hand, Trump traveled this Friday to Florida, a key state, and Georgia, an old Republican stronghold. Democrat Joe Biden, for his part, He spent the day in Michigan, a northern state that the Republican narrowly won in the 2016 election.
INTERNATIONAL DRAFTING * With AFP *
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