Since COVID-19 entered our lives more than a year ago, scientists have been able to determine certain risk factor’s so that people present serious pictures of the disease. Among them are the advanced age, the male Y comorbilidades such as cardiovascular or respiratory diseases.
To these elements we must now add the genetic variants of each host, according to a recent study published in Genetics in Medicine. A team of researchers has observed that people with a partial or total absence of the NKG2C receptor tend to develop severe disease courses: “Our data show that these genetic variants in the eje NKG2C / HLA-E they have a significant impact on the development of serious SARS-CoV-2 infections and can help identify patients at high risk for severe COVID-19 ”. This genetic variation was found mainly in COVID patients who had to be hospitalized.
Specifically, it is the lack in the immune system of a receptor lacking about 4% of the population, explains virologist Elisabeth Puchhammer-Stöckl in a release issued this Monday by the Vienna Medical University (UniMed). “The absence of the receiver was especially common in patients who had to be treated for COVID-19 in intensive care unitsregardless of age or gender, ”he explains.
The UniMed note also recalls that “The interaction between the SARS-CoV-2 virus and the human immune system significantly influences the course and severity of COVID-19”In this context, “the antiviral immune response by natural killer (NK) cells it is normally an important step to combat viral replication during the initial phase of infection ”, adds Puchhammer-Stöckl.
The so-called NK cells (Natural Killer, in English), natural killers or killer cells is an important lymphocyte of the immune system for the defense of the body. They have specific activating receptors on their surface, including the NKG2C receptor, which communicates with an infected cell through one of its specific structures, HLA-E. This interaction leads to the destruction of cells infected by the virus, but “about 4% of the population naturally lacks the activating receptor NKG2C due to genetic variation, and about 30% only partially owns the receiver”, Highlight the scientists.
“The genetic variations in HLA-E of the infected cell were also associated with the severity of the disease, although to a lesser extent ”, says Puchhammer-Stöckl.
These discoveries could open the doors to new formulas to combat the pandemic, says the virologist and professor. “This part of the immune response could be an important target for drug (development) that could help prevent the serious illness of COVID-19, “he says.
For their part, the study authors also emphasize that “revealing these NK cell-driven antiviral mechanisms could be of great importance in gaining a better understanding of immune responses protective against SARS-CoV-2 ”.