US President Donald Trump announced that his government would ban flavored electronic cigarettes after a series of vaping-related deaths.
Trump told reporters that vaping was a "new problem", especially for children.
US Secretary of Health Alex Azar said the Food and Drug Administration (FDA) would finalize a plan to remove all tobacco-free flavors from the market.
There were six deaths and 450 reported cases of pulmonary disease related to vaping in 33 states.
Of the 450 reported cases, many are 19 year olds on average.
Michigan this month became the first state in the US to ban flavored electronic cigarettes.
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Joining Trump at the White House on Wednesday, Azar said it would take several weeks for the FDA to release new indications on e-cigarettes.
He also said that the agency would take enforcement action if it decided that children were intentionally attracted to e-cigarettes.
The first American lady, Melania Trump, said this week that she was "deeply concerned about the growing epidemic of electronic cigarette use in our children".
She was present at Wednesday's announcement alongside the President, Mr. Azar and FDA officials.
What did Mr. Trump say?
Trump told reporters that his administration would enforce strict rules to protect "innocent children," including his 13-year-old son, Barron.
"We can not allow people to get sick and our youth can not be so affected," he said.
"That's how the first lady gets involved." She has a son, together, is a handsome young man and she feels very, very strong.
"She saw it, we both read it, many people read it, but people are dying of fear, so we look at it very closely.
He added that he hoped this announcement would make parents "tougher".
"People will watch what we say and parents will be much harder about their children," said the president.
"A lot of people think that vaping is wonderful, it's great, it's really not wonderful."
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In a press release issued shortly after Trump's announcement, the state secretary for health said that officials "will not sit idly by," while a generation is becoming Nicotine dependent.
Acting FDA Commissioner Dr. Ned Sharpless said: "If we observe a migration of children to tobacco-flavored products, we will take additional measures to combat the use of these products by young people. ".
Manufacturers of electronic cigarettes such as Juul have been accused of having fueled children's addiction through flavored products such as mango, cream or cinnamon bread.
Juul, which dominates the electronic cigarette market, stopped selling most of its flavored appliances last year in order to defuse growing critics.
What causes the disease?
Health officials are still investigating whether a particular toxin or substance is causing spray-related illness or whether it's a use intensive.
The first death occurred in Illinois at the end of August. Since then, five more people have died and hundreds have been sick in 33 states.
The cause of the vaping disease has not yet been determined by health officials.
THC, the psychoactive chemical contained in cannabis, was present in some devices used by those who became ill, according to the authorities.
The FDA has stated that many products contain significant amounts of vitamin E acetate, an oil used to thicken vaping liquid.
Several patients have been suffering from lipoid pneumonia, which occurs when someone inhales fats or oils.